Cancer

Pharmacogenetics has an increased role in cancer treatment.[13] CYP2B6 metabolizes several anticancer drugs, among them cyclophosphamide, and preliminary indications exist for an increased metabolism among subjects carrying a variant allele, CYP2B6*6. Tamoxifen is metabolized to its active metabolite by CYP2D6, and a smaller therapeutic effect has been observed in PMs for CYP2D6 and predictive phenotyping/genotyping could be relevant before entering the treatment.[14] The effect of antiemetic drug treatment of cancer patients with drugs such as the 5-hydroxytryptamine type 3 receptor antagonists tropisetron and ondansetron has been found to be highly related to the CYP2D6 phenotype. Lower plasma levels and higher frequency and intensity of vomiting were seen in subjects carrying more active gene copies of CYP2D6.[15]

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment