Pharmacogenetics has an increased role in cancer treatment. CYP2B6 metabolizes several anticancer drugs, among them cyclophosphamide, and preliminary indications exist for an increased metabolism among subjects carrying a variant allele, CYP2B6*6. Tamoxifen is metabolized to its active metabolite by CYP2D6, and a smaller therapeutic effect has been observed in PMs for CYP2D6 and predictive phenotyping/genotyping could be relevant before entering the treatment. The effect of antiemetic drug treatment of cancer patients with drugs such as the 5-hydroxytryptamine type 3 receptor antagonists tropisetron and ondansetron has been found to be highly related to the CYP2D6 phenotype. Lower plasma levels and higher frequency and intensity of vomiting were seen in subjects carrying more active gene copies of CYP2D6.
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