Cause and Laboratory Diagnosis

EDS dermatosparaxis type and the related animal disease dermatosparaxis are recessively inherited connective tissue disorders, caused by a deficient activity of pro-collagen-I-N-proteinase, the enzyme that excises the N-terminal propeptide in procollagen type I, type II, and type III. As a consequence, there is accumulation of pN-procollagen,[20] resulting in polymerization of abnormal collagen fibers that appear thin, irregular, branched and ''hieroglyphic'' in cross section.[21] The diagnosis can be made based on these characteristic clinical, biochemical, and electromicroscopic findings. Molecular confirmation of the diagnosis is available on a research basis. Homozygous mutations in the gene encoding procolla-gen-I-N-proteinase or ADAMTS-2 (a disintegrin and metalloproteinase with thrombospondin-like repeats), an enzyme belonging to an expanding family of zinc metalloproteinases found in vertebrates and invertebrates, have been identified in all reported patients with dermatosparaxis.[22]

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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