EDS dermatosparaxis type and the related animal disease dermatosparaxis are recessively inherited connective tissue disorders, caused by a deficient activity of pro-collagen-I-N-proteinase, the enzyme that excises the N-terminal propeptide in procollagen type I, type II, and type III. As a consequence, there is accumulation of pN-procollagen, resulting in polymerization of abnormal collagen fibers that appear thin, irregular, branched and ''hieroglyphic'' in cross section. The diagnosis can be made based on these characteristic clinical, biochemical, and electromicroscopic findings. Molecular confirmation of the diagnosis is available on a research basis. Homozygous mutations in the gene encoding procolla-gen-I-N-proteinase or ADAMTS-2 (a disintegrin and metalloproteinase with thrombospondin-like repeats), an enzyme belonging to an expanding family of zinc metalloproteinases found in vertebrates and invertebrates, have been identified in all reported patients with dermatosparaxis.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.