CD44 is a polymorphic family of immunologically related integral membrane glycoproteins associated with cellmatrix adhesion, lymphocyte activation and targeting, and tumor growth and metastasis. Some variant isoforms, especially those containing sequences encoded by v6-v10, are overexpressed in several human neoplasms, including thyroid cancer, particularly in the papillary variant. Reports of successful differentiation of thyroid papillary carcinoma from other lesions by CD44 immunostaining of thyroid fine-needle aspirates were followed by studies using RT-PCR to detect CD44 mRNA in leftover cells inside the needle used for FNAB.[2] These studies suggested that thyroid tumors may be more accurately diagnosed by a combination of cytological examination and detection of CD44 variants in RNA obtained by FNAB, in particular when coexpression of CD44v6 and galectin-3 was detectable. However, CD44 exons were also present in transcripts in a high proportion of benign samples. Taken together, in thyroid cancer the clinical applicability of CD44v detected by RT-PCR still has to be determined, in particular in the light of the excellent specificity and sensitivity of FNAB conventional cytology in papillary thyroid carcinoma (PTC).

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

Get My Free Ebook

Post a comment