Chemical Chaperones To Increase Enzyme Activity

The addition of subinhibitory concentrations of N-(n-nonyl)deoxynojirimycin (NN-DNJ) in fibroblast culture led to increased N370S p-glucocerebrosidase activity that persisted after withdrawal of the putative chaperone, suggesting that NN-DNJ chaperones the folding of mutated protein, stabilizing it for transport to the Golgi apparatus and hence proper trafficking to lysosomes. This modest increase in glucocerebrosidase activity may be sufficient to achieve a therapeutic effect.[16]

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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