Circulatory Nucleic Acids Role In Detecting Highrisk Pregnancies

The observation that cell-free fetal DNA concentrations are elevated in pregnancies with certain fetal aneuploidies or pregnancy-related disorders, such as preeclampsia, have led to the suggestion that this may serve as a marker for such pregnancies. This is further supported by two independent studies, which have indicated that the levels of circulatory fetal DNA are elevated early (second trimester) in those pregnancies that later develop pre-eclampsia.1-20'21-1 Unfortunately, these studies are too small to provide any indication of the possible predictive value. An examination of second-trimester fetal DNA levels has indicated a minimal increase in sensitivity for the detection of trisomy 21 fetuses when combined with the analysis of other serum analytes. The proposal that the analysis of circulatory fetal DNA could aid in the distinction between true and false preterm labor (i.e., those that do not respond to tocolytic treatment and still deliver prematurely, and those that respond and deliver at term) could, unfortunately, not be confirmed in a larger study.

It is perhaps in this area that the analysis of circulatory mRNA species will come to the fore, as apart from not being restricted by fetal sex, the description of mRNA species overtly expressed in the placenta of tri-somy 21 placentae[22- may aid in the development of aneuploidy-specific screening tests. It is also possible that preeclampsia may be associated with the upregulation of different mRNA species when compared to other pregnancy-related disorders, such as preterm labor. This distinction may lead to the development of specific diagnostic or screening markers.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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