The genetic applications of inverse PCR have been widespread and diverse. They include:
1. characterization of long stretches of unknown DNA sequence adjacent to specific genes, e.g., chromosome mapping/walking and identification of upstream and downstream regulatory elements;
2. establishing the insertion sites of mobile genetic elements, including the integration of viral genomes into the host;[13-15]
3. aiding in the understanding of mutational mechanism involved in deletions and translocations;1-16-1
4. the construction of knockout vectors to disrupt
5. fingerprinting of microorganisms;[18,19]
6. evolution of organisms;
7. generation of end-specific probes.
8. defining new pathways of disease;
9. determining the differential expression of genes.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.