LD-PCR has extensive uses as a supplement to cloning, as a time and cost-saving alternative, or where the DNA sequence is unclonable. They include the following:
1. Detection of DNA mutations such as:
a) deletions within human mitochondrial DNA (mtDNA) and viral genomes.
b) insertions, e.g., duplications, in human mtDNA.
c) rearrangements, e.g., inversions in disorders such as hemophilia.[8,18]
2. Chromosomal and genetic analysis of single cells for possible medical, forensic, and archaeological pur-poses.
3. Typing of genetic markers for genome diversity studies.
4. It has now been adapted to perform long-distance RT-PCR and long-distance vectorette PCR.
5. Fingerprinting of organisms by amplification of specific interspersed repetitive elements.
6. Characterization of unknown, unclonable, long DNA
7. Analysis of viral heterogeneity to aid in drug design and viral association in certain disorders.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.