Clinical Aspects Of Superantigenmediated Diseases

S. pyogenes represent a potent threat to both healthy and immunocompromised individuals. These bacteria release, besides the SAgs described here, a wide array of potentially harmful cytolytic toxins and exoen-zymes.[1,2,4,12] As mentioned above, the production of these effectors during host infection by GAS contributes to a broad spectrum of diseases ranging from mild to severe cutaneous and other tissue infections, to life-threatening septicemia and toxic shock syndrome. A detailed description is beyond the scope of this review. We will summarize here the major aspects of STSS (reported death rate of 30% to 70%) mainly mediated by

SAgs.[1,2,4,22] This illness is a significant portion of invasive S. pyogenes cases such as painful cellulitis, soft-tissue infections (necrotizing fasciitis, myonecrosis), bacteremia, deep-seated infections preceded by blunt trauma, muscle strain, hematoma, or joint effusion at the infection site. The early symptoms of STSS are often flulike including myalgia, chills, and fever. Severe localized pain is a hallmark of the illness. These symptoms are followed by persistent fever, systolic hypotension, and shock. Multiorgan failure and tachycardia may occur as well fasciitis and myositis. Disseminated intravascular coagulation may lead to impaired circulation and subsequent gangrene of the limbs and ultimately death.[4,22]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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