Clinical Description And Diagnosis Clinical Description

Clinical symptoms are similar in both Sanfilippo subtypes. They usually occur after 2 years of apparently normal development and include hyperactivity, aggressive behavior, delayed development (particularly in speech), sleep disturbances, coarse hair, hirsutism, and diarrhea. There are only relatively mild non-CNS manifestations and this may be the reason why Sanfilippo patients present later than other MPS patients. Following the hyperactive and aggressive phase there is then a period of progressive mental retardation with death usually between the second and third decade of life. In both Sanfilippo A and B a small number of more slowly progressive forms with later onset have been described.[1,2] An adult Sanfilippo A patient was recently described who presented with cardiomyopathy at 45 years and, interestingly, had no neurological symptoms.[3]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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