Among immunocompetent patients, resistance to ACV is rare, with a prevalence below 1% and most often detected in the course of recurrent genital herpes. In this situation, the observed prevalence ranged from 3.5% to 8.6%, and in most cases, clinical course was unchanged.
Prevalence of ACV resistance among immunocompro-mised patients is about 5% according to several published reports recently reviewed by Bacon et al. But this global incidence has to be specified according to the type of immunosuppression as resistance may be detected in up to 25% of allogeneic bone marrow transplant patients presenting with an HSV infection.
Among immunocompromised patients, resistance is associated with clinical failure after 7 to 14 days of treatment. Lesions may present as large, ulcerated, and extensive. These infections are often serious and may become chronic. After healing, recurrent infections are most often associated with an ACV-sensitive strain, but some cases of recurrences due to an ACV-resistant virus have been reported.[11-14]
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.