Clinical Description And Epidemiology

Among immunocompetent patients, resistance to ACV is rare, with a prevalence below 1%[6] and most often detected in the course of recurrent genital herpes. In this situation, the observed prevalence ranged from 3.5%[7] to 8.6%,[8] and in most cases, clinical course was unchanged.

Prevalence of ACV resistance among immunocompro-mised patients is about 5% according to several published reports recently reviewed by Bacon et al.[6] But this global incidence has to be specified according to the type of immunosuppression as resistance may be detected in up to 25% of allogeneic bone marrow transplant patients presenting with an HSV infection.[9]

Among immunocompromised patients, resistance is associated with clinical failure after 7 to 14 days of treatment. Lesions may present as large, ulcerated, and extensive. These infections are often serious and may become chronic.[10] After healing, recurrent infections are most often associated with an ACV-sensitive strain, but some cases of recurrences due to an ACV-resistant virus have been reported.[11-14]

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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