Clinical Features And Treatment

C. difficile infection has been shown to cause a wide spectrum of intestinal symptoms including mild to severe diarrhea, chronic diarrhea, colitis, pseudomembranous colitis, and toxic megacolon.[2] Although C. difficile is occasionally isolated in extraintestinal pathologies, these cases are infrequent and usually involve a polymicrobial infection. Typically, C. difficile-associated diarrhea appears within 1-2 weeks following the administration of an antibiotic. Watery stools may contain mucus and sometimes blood. Patients may present fever, abdominal cramps, and leukocytosis. However, even severe cases may present no diarrhea or just loose stools. Radiographic evidence of distended colon can indicate toxic megacolon. Prolonged or severe disease can be complicated by dehydration problems, bowel perforation, and death. Diagnosis is based on history of recent or ongoing antibiotherapy, appearance of diarrhea or other symptom of colitis, and demonstration of infection by toxigenic C. difficile.

Treatment should begin by discontinuing the incriminated antibiotic whenever possible. However, this measure alone will resolve diarrhea in only one fifth of patients. Therefore, in cases with severe diseases or other comorbid conditions, anti-C. difficile antibiotics such as metronidazole and vancomycin are the first two drugs of choice for specific C. difficile therapy. Treatment of asymptomatic carriers is not recommended because antibiotics may prolong excretion of the bacteria.[12] On discontinuation of anti-C. difficile antibiotherapy, approximately 20% of patients experience recurrence of the infection. This situation can be explained by relapses

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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