Clinical Features

Pseudoxanthoma elasticum clinically affects three different organs of the body, namely, the skin, the eye, and the cardiovascular system. Initially, manifestations on the skin include yellowish papules, which tend to coalesce into larger plaques in the predilection sites, such as the lateral neck, the axillae, groin, antecubital, and popliteal fossae, and which typically are present at puberty. In longstanding lesions, sagging of the skin may be observed, which presents a major cosmetic problem. Involvement of the eyes can be severe as newly formed, fragile blood vessels along fractures (angioid streaks) in the elastic fiber-rich Bruch's membrane behind the retina often rupture and bleed, which leads to loss of central vision around the age of 40. Calcification in the cardiovascular system causes atherosclerotic disease often with morbid consequences beginning in young adulthood. While age of onset is variable and clinical manifestations are protean and differ significantly even within families, no racial or ethnic predilection has been observed.[1,6]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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