Clinical Findings

The hallmarks of the disease are hepatomegaly, hypoglycemia, lactic acidosis, hyperuricemia, hyperlipidemia, and growth retardation. Long-term complications include short stature, osteoporosis, gout, renal disease, pulmonary hypertension, and hepatic adenomas. Virtually all females have ultrasound findings consistent with poly-cystic ovaries.[6] Hepatic adenomas develop in a significant number of patients, and malignant transformation

Type Ib has a similar clinical course with the addition of neutropenia and impaired neutrophil function resulting in recurrent bacterial infections. Oral and mucosal ulcerations are common, and in some cases, regional enteritis can also occur.[8]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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