Familial adenomatous polyposis exemplifies the classic hereditary cancer syndrome with Mendelian distribution. Its epidemiology reveals a rare disorder with high cancer-related mortality. Its clinical features are hallmarked by synchronous and metachronous tumor growth at an early age. Understanding the epidemiology, clinical characteristics, and genetics of FAP affords not only evidence-based preventive measures, but also allows for a better appreciation of the behavior of all hereditary cancer syndromes. Screening protocols are available, but not standardized and imperfect. As timely surgery on the primary organ has impacted mortality, the cancer-related deaths associated with extra primary sites continue to pose therapeutic dilemmas. Recent advances in molecular genetics and continued research in its genetic profile exposed an increased genotype-phenotype correlation, which may eventually influence the choice, accuracy, and effectiveness of genetic testing, screening recommendations, and chemoprevention strategies.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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