Tuberous sclerosis is a disorder that affects approximately 40,000 people in the United States. It is remarkable in several respects: the frequency and severity of associated epileptogenesis, the unique predisposition to autism and other behavioral syndromes, and the unusual spectrum of associated tumors including LAM. The placement of the TSC genes in the PI3 K-Akt-TSC1/TSC2-Rheb-mTOR signaling pathway explains the hallmark giant cells seen in cortical tubers and provides the possibility of several pharmacological approaches that may be helpful in TSC. This includes drugs already in use in the clinic, including rapamycin and analogues (inhibit mTOR), farnesyl transferase inhibitors (inhibit Rheb), angiogenesis inhibitors, and interferon-g. Current ongoing and planned trials of these agents in both preclinical models and TSC patients are of considerable clinical and basic interest.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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