The underlying defects of clinical heterogeneity in individuals with OI as well as the relationship between genotype and phenotype are still not completely understood. Current medical treatment with bisphosphonates aims to improve bone mass and is independent of both phenotype and genotype. However, bisphosphonates have 9. a prolonged half-life in bones, and their safety and efficacy have not been established in controlled trials in children. The heterogeneity of mutations in type I collagen genes poses many problems in planning new 10 strategies for OI treatment. Specific treatment will need to be directed to each affected individual's unique mutation. The continued creation of true animal models of OI and 11. the evaluation of each intervention are essential in the identification of an effective and safe therapy.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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