Conclusion

LightUp Probes provide a useful combination of strong affinity and high specificity. The resistance against degradation is an important advantage when storing and manufacturing diagnostic kits. Freeze-thaw cycles are often deleterious to long DNA, such as viral genomes and plasmids. This can be avoided by using LightUp Probe technology, because the probe does not need to be stored frozen. Furthermore, the probes can be made short: 8-12 residues is typical. This is a very useful property in viral diagnostics, where the mutation frequency often is high and long conserved target regions may be rare. This is particularly true for RNA viruses such as HIV, influenza, and severe acute respiratory syndrome (SARS). In fact, several probes could, in principle, be targeting the same amplicon-generating independent signals, thereby making the assay even more robust and less prone to false negatives. The greatest challenge for the future success of the LightUp Probe technology will be to develop and implement fluorescent dyes suitable for multiplex applications.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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