Fabry disease is a complex disorder with a wide clinical variation concerning the severity and onset of symptoms. As it has an influence on the quality of life and the survival rate of both affected males and females, enzyme replacement therapy is a major advancement for this disease. Therefore prompt and accurate diagnosis is now crucial to be able to initiate treatment before irreversible organ damage occurs. Many questions concerning appropriate time for therapy, choice of dose, long-term benefits, and risks still need to be addressed. Novel emerging therapies, such as substrate deprivation, enzyme enhancement by chemical chaperons, or gene therapy, are now in development.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.