Conclusion Genomics And Vaccination

Despite the advances associated with molecular techniques, meningococcal disease remains a globally significant health problem, and the prospect of comprehensive vaccination remains elusive. Whereas vaccines based on the capsular polysaccharide are either licensed or under development against meningococci associated with serogroups A, C, and Y, as well as W-135, attempts to develop a polysaccharide-based serogroup B vaccine have proven unsuccessful. This fact is especially relevant as much of the meningococcal disease in Europe and North America is caused by meningococci associated with the serogroup B capsule. A number of alternative approaches to the development of serogroup B meningo-coccal vaccines are currently in development,[14] and these are summarized in Table 1. The recent completion of three meningococcal genomes [(http://www.sanger. ac.uk/Projects/N_menigitidis/); Refs. [23,24]] has revolutionized the process of vaccine development and the application of genomic approaches such as reverse vaccinology to this resource has already led to the identification of novel vaccine candidates.1-25-1

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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