Conclusion

Diagnosis of C. pneumoniae is still unsatisfactory. Internationally standardized and validated assays especially for nucleic amplification and antibody detection are warranted. The first steps in this direction have been taken for example with the formulation of recommendations from the Centers of Disease Control (United States).[27] The standardization of diagnosis may eventually allow determining the contribution of C. pneumoniae in chronic inflammatory disease more precisely.

The known sequences of the chlamydial genomes were already the base for many elucidating studies and will be the base for further research.[8-11] Methods for the genetic transformation of chlamydiae are not in sight, but transcriptional analysis will further contribute to elucidate mechanisms of chlamydial infection by identifying the involved genes and their interplay. The microarray techniques are increasingly implemented for transcrip-tional profiling of global gene regulation and more results are soon going to be published.[35] Functional research on chlamydial proteins will also base on the expression of chlamydial proteins in transformable organisms such as Escherichia coli. Two-dimensional (2-D) gel electropho-resis is a promising technique for the analysis of protein expression in chlamydiae and some of the abovemen-tioned data have already been derived from 2-D gel electrophoresis partly in genomic-proteomic approach-es[3,4,6] (more contemporary information about chlamyd-iae and proteomics is available at http://www.gram.au.dk). In addition to enhancing the functional understanding of chlamydiae, proteomics might help to identify proteins for diagnostic purposes and even targets for the development of a vaccine.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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