Conclusion

Individual variations in responses to anticancer agents can be partly explained by genetic polymorphisms in their metabolizing enzymes. Genotype-phenotype correlations, however, are still poorly understood because epigenetic influences on gene expression make it difficult to estimate the exact effects of genetic conditions on the activities of metabolizing enzymes. To enable customized and individualized cancer chemotherapies in which the most favorable dosage and drug combination are administered, further studies should focus on parameters that are closely correlated with the pharmacokinetics and pharmacody-namics of an agent and on well-designed clinical trials to evaluate their clinical usefulness.

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