Conclusion

There is increasingly rapid progress in developing therapeutic applications of AAV vectors. The early clinical testing of AAV vectors for the treatment of CF was extremely important in initiating the regulatory environment for AAV vectors and demonstrating the inherent good safety profile of AAV vectors. As more groups have extended investigations to additional in vivo models, the potential utility of AAV vectors as therapeutic gene delivery vehicles has gained more widespread interest. The development of more sophisticated production systems for AAV vectors has enhanced both the quantity and quality of vectors that can be produced. Additional work to understand the intracellular metabolism of AAV vectors and modify the transduction efficiency by judicious choice of serotype or by modification of the capsid structure will expand the use and potency of AAV vectors. It is likely that in the next few years there will be a significant increase in clinical testing of AAV vectors for additional therapeutic applications.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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