Conclusion

Protein microarray applications are being applied to address the challenges of translational medicine. Mapping pathophysiological defects, via protein microarrays, is enhancing our ability to discern treatment effectiveness at an early time point during treatment, thus hopefully leading to early intervention and positive patient outcomes. The need for discovery and quantitative analysis of protein-protein interactions and posttranslational modifications will undoubtedly benefit from this technology. Protein microarrays are proving useful for penetrating into phosphorylation events that are not related to gene expression. The ability to draw a functional map of the state of key protein pathways within a patient's tumor cells will hopefully become the starting point for individualized therapy. Under this scenario, therapy may be tailored to the individual tumor's molecular defect, making it feasible to administer combination therapy targeting multiple interdependent points along a pathogenic pathway or targeting separate pathways.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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