Alpha-thalassemias are common hemoglobinopathies, very heterogeneous at clinical and molecular level. Four different clinical conditions of increased severity have been described: the silent carrier state, alpha-thalassemia trait, HbH disease, and Hb Bart's hydrops fetalis syndrome. HbH disease is a moderate, very rarely severe, microcytic, and hypochromic hemolytic anemia, whereas Hb Bart's hydrops fetalis syndrome is a condition not compatible with postnatal life. Deletion defects are more common than nondeletion defects. The carrier state is suspected by hematological methods, but the precise identification is possible with several PCR-based procedures or globin chain synthesis analysis. Prenatal diagnosis is only indicated for Hb Bart's hydrops fetalis syndrome.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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