The genetics of drug-metabolizing enzymes such as CYP2D6 and CYP1A2 is one major reason for the interindividual variability in drug therapy. Further investigations and large studies are required to elucidate the exact role of the polymorphisms of Cyp1A2*1F and Cyp2D6 in predicting therapeutic drug concentrations and clinical outcome, e.g., therapeutic response and adverse drug effects. Real-time PCR is one option to analyze the patients' genotype in a simple, fast, and reliable way. New functional relevant alleles will probably be found in the future, which can be easily and fast adapted for by this technique at limited cost. Screening prior to therapy is facilitated in a routine clinical setting. Once all major polymorphisms with functional relevance are characterized, microarray assays and gene chips will, in the future, probably offer even faster genotyping at lower cost.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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