All members of genus Orthopoxvirus share common morphological and biological characteristics notwithstanding the broad spectrum of their mammalian host repertoire that includes rodents, domesticated and feral mammals, humans and nonhuman primates. They differ from other double-stranded DNA viruses in that they are self-reliant in their replication strategy, as they replicate exclusively in the cell cytoplasm using a set of specialized enzymes, transcription, and replication factors. There are 11 recognized Orthopoxvirus species, five of which (buffalopox, cowpox, monkeypox, Vaccinia, and Variola viruses) are known to cause human disease with varied severity depending on the viral strain and host's immune response. Changes in certain protein genes or insertion of foreign genes into the genome may influence viru-lence.[13,14] Furthermore, Vaccinia virus, which has been used for years as a vaccine against smallpox, is still widely used as an expression vector for a variety of genes from numerous infectious agents. For these, and other reasons, there have been concerns that members of the

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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