The Ehlers-Danlos syndrome is a clinically and genetically heterogeneous group of connective tissue diseases. At least six different subtypes are currently recognized, and several fibrillar collagens are involved in the etiology of the condition. Structural mutations in collagen type I, III, and V are causal in the dominant subtypes of the condition, whereas recessive EDS subtypes are associated with defects in enzyme activity involved in the biosynthesis of type I collagen. Developments in the elucidation of the biochemical and molecular basis of EDS, together with increasing clinical experience, add a new dimension to diagnosis, genetic counseling, and management of these heritable disorders. Future research will further increase the understanding of the molecular mechanisms involved and open perspectives for gene therapy.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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