Highly frequent MSI (MSI-H) as a result of defective MMR affects about 15% of all CRC. Highly frequent MSI tumors differ from microsatellite-stable tumors in a number of molecular and clinicopathological features. Approximately 3% of CRC show MSI-H due to predisposing constitutional mutations in MMR genes. This group of patients is referred to as hereditary nonpolyposis colorectal cancer, HNPCC. Familial and sporadic MSI-H tumors are largely similar in their molecular characteristics, but differ in some clinicopathological features. Patients with MSI-H cancers respond differently to various chemotherapeutic treatment regimens compared to MSS CRC patients. Further prospective and population-based studies are needed for a better and individualized therapy stratification of CRC.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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