Achieving maximum efficiency and cost-effectiveness on microarrays requires that all test sites provide useful information. Standard high-density arrays are, therefore, best suited for research studies requiring analysis of very large numbers of SNPs. Such discovery efforts provide valuable insight into markers of potential clinical utility. Those markers must then be clinically validated and, ultimately, incorporated into panels for diagnostic or prognostic use. The demands in a clinical environment differ from those in a research setting: multiple samples must be analyzed in a cost-effective, time-efficient way, and the methods used must be highly accurate and robust. Electronic microarrays are ideally adapted to these clinical applications.

Individual control of each test site allows DNA from different samples to be analyzed simultaneously on a single microarray. Unused test sites remain available for subsequent addressing, allowing utilization of all micro-array sites regardless of the number of markers and samples being interrogated in any one experiment. The ability to analyze multiple SNPs from each sample provides the capacity necessary for development of complex genetic panels. Nanogen's open platform provides unique flexibility in assay design, allowing the user to reconfigure the panel of SNPs as additional information becomes available regarding the clinical utility of particular markers. The unique features of an electronic microarray not only provide the cost and time efficiencies required in a clinical laboratory setting, but also enable the validation and incorporation of new molecular diagnostic tests as new data are generated.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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