Preimplantation genetic diagnosis is a developing technology introduced in 1990 as an alternative to invasive prenatal diagnosis. The issue of pregnancy termination is avoided as genetic tests are performed before embryo transfer. Many would consider PGD ethically acceptable for cases where prenatal diagnosis would be offered. However, the clinical indications for PGD will widen and those performed for family balancing (sex selection) or other nondisease conditions (e.g., HLA-typing) are the most controversial. Whether PGD for aneuploidy screening will increase the success rate for IVF treatment is still being investigated.

Development in the field of PGD has been focusing on methods to eliminate any risks of misdiagnosis. For chromosome analysis, mosaicism is problematic and analysis of two blastomeres may increase the chance of detecting it. Ideally, a full chromosome analysis should be performed and techniques such as CGH are being adapted for PGD. In PCR, diagnostic errors can be reduced by using fluorescent PCR and informative markers in a multiplex reaction.

The overall impact of PGD is still low because of its complexity and relative costs. However, for couples at high risk of having an affected child, PGD may be an attractive alternative to prenatal diagnosis. For some couples PGD could even be the only available method that will enable them to have unaffected children.

100 Pregnancy Tips

100 Pregnancy Tips

Prior to planning pregnancy, you should learn more about the things involved in getting pregnant. It involves carrying a baby inside you for nine months, caring for a child for a number of years, and many more. Consider these things, so that you can properly assess if you are ready for pregnancy. Get all these very important tips about pregnancy that you need to know.

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