Medullary thyroid carcinoma is the first neoplastic manifestation in MEN 2, the only consistently malignant neoplasm in all phenotypical variants, and the most common cause of death in affected patients. Recent advances in genetic profiling and stratification of RET codon mutations have contributed to accurate genotype-phenotype correlation, proper genetic counseling, targeted surveillance, and timing and extent of prophylactic thyroidectomy in accordance with the natural history of this hereditary syndrome. Genetic testing in high-risk family members is strongly recommended. The available current data indicate superiority of surgical prophylaxis compared with biochemical surveillance in reducing MTC risk in carriers of RET mutations.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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