TTGE is a powerful method for mutation detection. It is simple, sensitive, high-throughput, and cost-effective. For nuclear gene mutations, the distinction between homozygous and heterozygous mutations is obvious. The identification of unknown heteroplasmic mtDNA mutations is more difficult. This is attributable to the limited sensitivity of direct DNA sequencing in the detection of low percentage of heteroplasmy. Very often, the TTGE showed the presence of heteroplasmic mutations but sequencing failed to score the mutation.
Was this article helpful?
The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.