Comparative genomic hybridization was originally developed as a cancer research tool and rapidly demonstrated its power by detecting novel regions of chromosomal imbalance in a large variety of neoplastic samples. These studies have led to the discovery of many new tumor suppressor genes and oncogenes that play a role in the initiation and/or progression of solid tumors. The application of CGH to prenatal and pediatric samples has also proven extremely beneficial, allowing the delineation of ambiguous and complex karyotypes that could not be defined using classical cytogenetic techniques. In addition, the use of CGH to analyze human preimplantation embryos has provided fascinating scientific data concerning the variety and rate of aneuploidy at this early developmental stage and holds a lot of promise for improving the efficiency of assisted reproductive techniques.

As technical advances improve the capabilities of CGH, future additional applications are likely to include screening for deletions as small as those observed in the microdeletion syndromes such as Prader-Willi and DiGeorge syndromes. This will be made possible by the recent development of newer CGH protocols such as matrix CGH which combines biochip and CGH technol-ogies[19] and array CGH which uses an array of DNA sequences instead of metaphase chromosomes.[20] The use of regular CGH would still remain an attractive and powerful accessory to routine clinical cytogenetic analysis.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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