p-Thalassemias are very heterogeneous at the clinical and molecular level. Clinically, we distinguish four clinical-hematological conditions of increasing severity, i.e., silent p-thalassemia, the p-thalassemia carrier state, thalassemia intermedia, and thalassemia major. At molecular level, p-thalassemias result from more than 200 different molecular defects. Molecular detection is possible with several PCR-based procedures. Preconception and prenatal diagnosis is available. Carrier screening and genetic counseling in the Mediterranean population at risk have led to a dramatic decrease in the birth rate of homozygous p-thalassemia. Treatment, based on periodic transfusion and iron chelation, has resulted in extended survival. Bone marrow transplantation from HLA identical siblings results in a >90% disease-free survival in patients in good clinical conditions. The lentivirus-mediated transfer of the p-globin or g-globin gene in a thalassemic mouse has recently produced encouraging results.

Pregnancy And Childbirth

Pregnancy And Childbirth

If Pregnancy Is Something That Frightens You, It's Time To Convert Your Fear Into Joy. Ready To Give Birth To A Child? Is The New Status Hitting Your State Of Mind? Are You Still Scared To Undergo All The Pain That Your Best Friend Underwent Just A Few Days Back? Not Convinced With The Answers Given By The Experts?

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