Conclusion

Von Hippel-Lindau disease is a multisystem disorder requiring a multidisciplinary approach, with regular imaging and biochemical analyses required to monitor affected patients and identify disease in its early stages. Genetic screening to identify germline VHL mutations, enabling targeting of affected individuals for vigilant clinical surveillance, is an important component of the clinical management of at-risk members in VHL families. As our knowledge of pVHL and the molecular pathways in which it functions increases, future treatment options in the form of molecular target drugs may provide an alternative, or an adjunct, to the surgical intervention offered today for tumors such as PHEOs and CCRCC, the latter of which is the greatest cause of mortality in VHL.

Online information specifically for the VHL patient is available at: http://www.vhl.org. Detailed reviews recommended for further reading on this subject include Maher and Eng,[13] Lonser and colleagues,[7] and Bryant and colleagues.[9]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

Get My Free Ebook


Post a comment