Epstein-Barr virus is clearly related to a number of acute and malignant diseases. However, pathogenesis is mainly dependent on insufficient immunosurveillance and cofac-tors such as continuous overstimulation of the immune system, chemicals and diet, and genetic predisposition. Against the background of the high prevalence of the virus within any population, demonstration of EBV infection by serology or by PCR is not sufficient to confirm an EBV-associated disease. Careful analysis of more specific serological markers with respect to particular viral antigens and different classes of immunoglobulins as well as virus load and clonality and physical presence of EBV in the affected tissues and the malignant cells is necessary to discriminate EBV-associated disease from the normal carrier state or opportunistic reactivation. In addition, determination of the cellular immunity against EBV might become an important tool for early diagnosis. In the end, a vaccine against EBV would be desirable to timely treat individuals who are at high risk to develop EBV-associated diseases.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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