The padlock probe represents the next generation of probe-based hybridization with the ability of direct target detection. The padlock probe improves the binding affinity and hybridization stringency and allows more efficient SNP discrimination. With the use of different fluorescent-labeled padlock probes, multiplex padlock assays could greatly increase throughput in genotyping and permit highly sensitive and specific measurement of gene expression. The padlock probe and its amplifications (i.e., rolling circle amplification and ramification amplification) allow for broad applications in clinical testing, research laboratories, and drug discovery. Clinically, it can be used for detection and identification of infectious agents, cancer screening and diagnosis, neonatal genetic diagnosis and parentage, and forensic testing.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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