The high level of accuracy of fetal RhD genotyping obtained by different groups could enable this technique to be offered on a routine basis for the management of RhD-negative patients during the first trimester of pregnancy. This strategy offers many advantages. The potential risk for maternal infection from contaminated anti-D Ig has to be taken into consideration, and women should be informed of the risk involved.[22] Even if anti-D product was safe with regards viral transmission, the risk could not be formally excluded. Moreover, as unnecessary infusion of anti-D Ig would be avoided, this strategy could contribute to saving this limited product until clonal anti-D becomes available. First-trimester determination of RhD fetal status is of interest because several clinical events may be responsible for RhD alloimmunization very early in pregnancy, such as therapeutic or spontaneous abortion and bleeding. In case of an RhD-negative fetus, no further biological and clinical investigations should be performed during the rest of the pregnancy.

First-trimester pregnancy is a critical period for prenatal diagnosis using noninvasive and invasive procedures. The PCR assays actually used need to be evaluated on a large-scale population,[2,22] and could lead to a combined systematic analysis of fetal RhD genotyping in RhD-negative women in the first trimester, in conjunction with fetal nuchal translucency and Down's syndrome screening test by serum biochemical markers.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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