Because the coevolution of the legionellae-protozoa interaction can be viewed as a ''living fossil'' of the adaptation of bacteria to professional phagocytes this pathogen has become a prominent model system in this respect. Main characteristics of the intracellular lifestyle and the regulation and function of replication- and pathogenicity-associated genes have already been elucidated. In addition, detection of legionellae by molecular methods has taken a significant role in clinical as well as in environmental diagnostics. The characterization of the genetic diversity of different Legionella species will provide information about the core genome of Legionella and genes present only in certain isolates. This may allow the identification of marker genes that can be used as tools for detection and risk assessment. In a long perspective, the molecular approach may also help to understand the infection cycle and the life cycle in the environment, which is the prerequisite for successful elimination of Legionella from high-risk areas.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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