Conclusion

PWS is the result of the deficiency of imprinted gene(s) in the chromosomal region 15q11q13. Although no single gene was shown to be a major contributor for the phenotype, SNURF-SNRPN and NDN are strong candidates. The typical PWS phenotype is most likely the result of deficiency of more than one gene, and thus fits the definition for continuous gene syndrome. DNA methyl-ation testing in combination with chromosome analysis will identify all PWS cases, but further testing may be required to determine the patient subtype. Future research on this condition may address the higher prevalence of psychotic manifestations in PWS patients with UPD. In addition, the long-term effects of growth hormone therapy on PWS need to be evaluated.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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