It would probably be fair to say that mutation detection in the CFTR gene has been simultaneously one of the greatest successes and one of the greatest disappointments of the molecular genetic testing era. It is perhaps unfortunate, but endlessly instructive, that the first genetic disease targeted for widespread population screening by molecular methods has proven to be so complex at both the genotypic and phenotypic levels. For these reasons, molecular diagnostic laboratories and genetic counselors are still struggling to meet the challenge of delivering and explaining this complex test to large populations of generally healthy people who are not personally familiar with the disorder. Such widespread screening would not even be conceivable without the availability of user-friendly DNA array technologies, and the perceived market afforded by large-population screening has induced manufacturers to develop and market such products as analyte-specific reagents. These products are well adapted to screening for a limited number of CFTR mutations (e.g., the standard screening panel of 25 in the United States), but it is clear that a new generation of array techniques will be required if the screening panels are to be expanded appreciably. A number of manufacturers are working on such products, although even if technically robust, expanded mutation panels bring with them yet another level of clinical complexity and genetic counseling challenges. In this way, the CF testing situation provides a foretaste of what we may expect as we embark on molecular genetic screening for even more complex diseases in the future.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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