There is intense activity to systematize the genomic, genetic, transcriptomic, and proteomic descriptions of organisms. A supplement to Nature Genetics ''The Chipping Forecast'' considered in detail the shift from hypothesis-led to descriptive hypothesis-forming research in the biosciences.1-19-1 The systems that we have described here incur no substantial capital costs. Reagent costs are minimal and, in general, gel-based assays represent well-understood, widely available, adaptable methods. The system is thus readily accessible to almost any standard laboratory. With a capacity up to 1 million tracks per day for minimal investment, the achievable throughputs for low-resolution electrophoresis by ''dry'' gel PAGE MADGE match the current shift of philosophy in biosciences research toward higher throughput, systematic description. Similarly, the throughputs with meltMADGE are two orders of magnitude greater than the currently favored approaches of SSCP and denaturing HPLC. Microplate array diagonal gel electrophoresis and melt-MADGE may meet the criteria of economy, sample parallelism, convenience of setup, and accessibility to large and small laboratories alike, and may thus find an important role in diagnostic, as well as research, applications. Future applications might also include enzyme, protein, RNA, protein-DNA, and other categories of biomolecular analysis.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.