Our knowledge of the key role of factor IX in hemostasis and the structure and function of the FIX gene and protein has greatly expanded. The cloning and expression of the factor IX gene has yielded important advances in both the diagnosis and treatment of hemophilia B. Genetic analysis in this disorder has increased our understanding of the function of the factor IX protein and facilitated accurate carrier analysis. In addition, the production of recombinant factor IX concentrate has greatly improved safety of therapy, and gene replacement therapy has the potential to cure or ameliorate this congenital bleeding disorder.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.