With the recent and more accurate studies of the genotype-phenotype relationship, it is now clear that the laboratory phenotype of congenital FX deficiency is largely a function of the FX gene lesion segregating in the family. However, some interesting cases have been reported that suggest more intricate mechanisms as responsible for congenital FX deficiency. In particular, symptomatic patients with autosomal dominant pattern of inheritance have been reported, leading to the hypothesis that the presence of a circulating abnormal FX protein can compete and exert a dominant negative effect by denying the access of the product of the wild-type factor X allele to receptor sites. Larger-scale studies of patients and their immediate relatives will provide more insight into the pathophysiology of congenital FX deficiency.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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