Rapid and accurate diagnosis of bloodstream infections by PNA-FISH is an important application utilizing the unique attributes of PNA probes to provide important diagnostic information in time to support the selection of appropriate antibiotic therapy. Furthermore, PNA-FISH has several similarities to standard staining technique, making it easily adaptable for routine testing without the need for specialized equipment, laboratory facilities, or personnel, as often required for molecular techniques.
It is well accepted that empirical use of antibiotics plays an important role in the spread and emergence of antibiotic resistance, and that a more appropriate use of antibiotics requires new and rapid diagnostic tests to change from empirical treatment practices based on clinical symptoms and worst-case scenarios to more personalized therapies based on individual diagnostic information. The speed and accuracy, combined with the simple and universal assay procedure, make PNA-FISH a promising tool for the development of therapy-directing diagnostics—the new generation of diagnostics.
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