Conclusion

In conclusion, although not fully explored yet, molecular cytogenetic analysis is an invaluable tool in the clinical management of patients with hematological malignancies. Conventional cytogenetic and FISH analysis should be used in a complementary way. With the increasing number of new developments in FISH and molecular biology, it is important to understand the most appropriate techniques to apply to an individual case. RT-PCR offers an alternative to cytogenetics when the presence of the fusion gene is the only indicator required, but, in most cases, G-banding and FISH are the appropriate choice at diagnosis and provide additional important information in the follow-up of the patients. The challenge for the future is to bring these interests together.[15] The development of CHIP technology for a DNA leukemia-specific screening test may eventually replace routine cytogenetics and molecular screening as we know them today, but until then, cytogenetic analysis remains imperative.[1] The search continues for new recurring chromosomal abnormalities with prognostic significance and the genetic changes associated with them. This is essential to increase further the understanding of the molecular mechanisms of leukemogenesis.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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