The genetic polymorphism of the BChE gene is very common in the normal population. It can be detected by PCR-SSCP, PCR-RFLP, COP-PCR, or by directly sequencing the PCR product. The phenotype of BChE cannot exactly reflect the genotype. Genetic methods can be used to distinguish inherited hypocholinesterasemia from acquired. Distinct ethnic differences exist in the BChE gene. Muscle-relaxant drugs should be used carefully with patients having low serum cholinesterase.
Research on the polymorphism of the BChE gene may be useful in clarifying the mechanism and treatment of some nerve diseases.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.