The therapeutic potential of retroviral vectors was first recognized over a decade ago. Due mainly to their ability to integrate into the host genome and the potential for long-term gene expression, retroviral vectors have now become one of the most widely used vehicles for gene therapy. However, despite many beneficial modifications, retroviral vectors are limited by the inability to transduce nondividing cells and inconsistent levels of gene expression. Additionally, with the recent development of leukemia-like disease due to insertional mutagenesis in two patients enrolled in a retroviral vector clinical trial, the safety of retroviral vectors is now a significant concern.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.