Cytochromes P450

The cytochrome P450 enzymes participate in the metabolism of a huge number of xenobiotic chemicals. The polymorphic forms of P450s are many times responsible for the development of adverse drug reactions. It has been described that 56% of drugs which are cited in adverse drug reaction (ADR) studies are metabolized by polymorphic phase I enzymes of which 86% are P450s. One estimates that: 1) ADRs cost the U.S. society about $100 billion; 2) they cause more than 100,000 deaths annually in the United States; and 3) up to 7% of all hospital admissions are due to ADRs (see Ref. [2] for references). In addition, the costs for treating patients with polymorphic forms of P450s are much higher than for those carrying nonpolymorphic alleles.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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