Detection of Fine Mutation

In DMD cases that have no large recombination event, identification of the causative mutation remains a laborious goal because of the difficulty in detecting a single point mutation in the 3000-kb-sized gene. To facilitate the identification of mutations in the dystrophin gene, more than 99% of which is made up of introns, dystrophin mRNA that is 100 times smaller than the dystrophin gene has been analyzed.[9] Analysis of dystrophin mRNA expressed in lymphocytes leads to not only identification of rare genomic mutations, but also to disclosures of nonauthentic alternative splicing.[10-12] In addition, several ways to identify small mutations have been proposed.[13-17] In the advent of recent advances in mutation analysis techniques, more than 90% of DMD

cases are shown to have mutations in the dystrophin gene.[18'19]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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